E-Prime 18.104.22.168 (and later) is compatible with 64-bit operating systems. Please see the following Knowledge Base articles.
The necessary drivers are installed automatically during installation. You do not need to manually install the SRBox and Port Driver for 64-bit systems.
The drivers available for download on the web support site are generally only needed for E-Prime 1.x installations.
Attempting to install the 32-bit Port and SRBox drivers on a 64-bit system will result in the following error message: Error: -3
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